کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9031146 | 1130970 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Long term dietary methoxychlor exposure in rats increases sodium solution consumption but has few effects on other sexually dimorphic behaviors
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کلمات کلیدی
XenoestrogenDDT, Dichlorodiphenyltrichloroethane - DDT، DichlorodiphenyltrichloroethaneGD, gestational day - GD، روز بارداریHPLC, high pressure liquid chromatography - HPLC، کروماتوگرافی مایع با فشار بالاPND, postnatal day - PND، روز پس از زایمانppm, parts per million - ppm، قطعات در میلیونEndocrine disrupter - اختلال غدد درون ریزANOVA, Analysis of variance - تحلیل واریانسSexually dimorphic - جنسی دیمورفیکDevelopmental - رشدMethoxychlor - متوکسی کلر
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Long term dietary methoxychlor exposure in rats increases sodium solution consumption but has few effects on other sexually dimorphic behaviors Long term dietary methoxychlor exposure in rats increases sodium solution consumption but has few effects on other sexually dimorphic behaviors](/preview/png/9031146.png)
چکیده انگلیسی
Methoxychlor is an insecticide with estrogen-like activity, thus exposure during development might cause sexually dimorphic behavioral alterations. To evaluate this, pregnant rats consumed diets containing 0, 10, 100 or 1000Â ppm methoxychlor from gestational day 7, and offspring continued on these diets until postnatal day (PND) 77. Assessments of sexually dimorphic behaviors in offspring indicated that intake of a 3.0% sodium chloride solution was significantly increased (41%) in males and females of the 1000Â ppm group. No treatment group differed from controls in open field nor running wheel activity, play behavior, nor 0.3% saccharin solution intake. Offspring of the 1000Â ppm group showed significantly decreased body weight, reaching 17% less than controls at PND 77, but not clearly related to their salt solution intake. During pregnancy, 1000Â ppm dams consumed 23% less food and weighed 10% less than controls, but this did not affect litter outcomes. These results indicate that in rodents, developmental and chronic exposure to dietary methoxychlor alters the sexually dimorphic behavior of salt-solution intake in young adults of both sexes. Similar behavioral alterations with other xenoestrogens, and the potential for interactions among xenoestrogens, suggest that this report may minimize the true effects of dietary methoxychlor exposure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 43, Issue 9, September 2005, Pages 1345-1354
Journal: Food and Chemical Toxicology - Volume 43, Issue 9, September 2005, Pages 1345-1354
نویسندگان
K.M. Flynn, K.B. Delclos, R.R. Newbold, S.A. Ferguson,