کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9032203 | 1131738 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Review of a Proposed Mechanism for the Antinociceptive Action of Botulinum Toxin Type A
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Review of a Proposed Mechanism for the Antinociceptive Action of Botulinum Toxin Type A Review of a Proposed Mechanism for the Antinociceptive Action of Botulinum Toxin Type A](/preview/png/9032203.png)
چکیده انگلیسی
Botulinum toxin type A (BOTOX®) has been used to treat pathological pain conditions although the mechanism is not entirely understood. Subcutaneous (s.c.) BOTOX® also inhibits inflammatory pain in the rat formalin model, and the present study examined whether this could be due to a direct action on sensory neurons. BOTOX® (3.5-30Â U/kg) was injected s.c. into the subplantar surface of the rat hind paw followed 1-5 days later by 50Â mL of 5% formalin. Using microdialysis, we found that BOTOX® significantly inhibited formalin-induced glutamate release (peak inhibitions: 35%, 41%, and 45% with 3.5, 7, and 15Â U/kg, respectively). BOTOX® also dose dependently reduced the number of formalin-induced Fos-like immunoreactive cells in the dorsal horn of the spinal cord and significantly (15 and 30Â U/kg) inhibited the excitation of wide dynamic range neurons of the dorsal horn in Phase II but not Phase I of the formalin response. These results indicate that s.c. BOTOX® inhibits neurotransmitter release from primary sensory neurons in the rat formalin model. Through this mechanism, BOTOX® inhibits peripheral sensitization in these models, which leads to an indirect reduction in central sensitization.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroToxicology - Volume 26, Issue 5, October 2005, Pages 785-793
Journal: NeuroToxicology - Volume 26, Issue 5, October 2005, Pages 785-793
نویسندگان
K.R. Aoki,