کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9032893 | 1131843 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Human neural tube defects: Developmental biology, epidemiology, and genetics
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Human neural tube defects: Developmental biology, epidemiology, and genetics Human neural tube defects: Developmental biology, epidemiology, and genetics](/preview/png/9032893.png)
چکیده انگلیسی
Birth defects (congenital anomalies) are the leading cause of death in babies under 1 year of age. Neural tube defects (NTD), with a birth incidence of approximately 1/1000 in American Caucasians, are the second most common type of birth defect after congenital heart defects. The most common presentations of NTD are spina bifida and anencephaly. The etiologies of NTDs are complex, with both genetic and environmental factors implicated. In this manuscript, we review the evidence for genetic etiology and for environmental influences, and we present current views on the developmental processes involved in human neural tube closure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurotoxicology and Teratology - Volume 27, Issue 3, MayâJune 2005, Pages 515-524
Journal: Neurotoxicology and Teratology - Volume 27, Issue 3, MayâJune 2005, Pages 515-524
نویسندگان
Eric R. Detrait, Timothy M. George, Heather C. Etchevers, John R. Gilbert, Michel Vekemans, Marcy C. Speer,