کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9034666 | 1132632 | 2005 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of cytokine treatment on the neurogenesis process in the brain of soman-poisoned mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effect of cytokine treatment on the neurogenesis process in the brain of soman-poisoned mice Effect of cytokine treatment on the neurogenesis process in the brain of soman-poisoned mice](/preview/png/9034666.png)
چکیده انگلیسی
On post-soman day 9, the cytokine treatment had no effect on the proliferation of neural progenitors in the SVZ and SGZ, as assessed by BrdU immunochemistry. However, this treatment seemed to promote the migration of neural precursor cells from the proliferative areas towards damaged brain regions. Indeed, in the CA1 hippocampal layer of soman-poisoned mice, on post-soman day 34, the cytokine treatment increased the number of healthy pyramidal neurons stained by hemalun-eosin dye. The cytokine treatment also augmented the number of BrdU-labeled cells in the CA1 hippocampal layer and amygdala. Interestingly, the administration of cytokines resulted in the differentiation of BrdU-positive cells into new neurons in the CA1 hippocampal layer, whereas astrocytic differentiation was preferentially observed in the amygdala.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 210, Issue 1, 15 May 2005, Pages 9-23
Journal: Toxicology - Volume 210, Issue 1, 15 May 2005, Pages 9-23
نویسندگان
Jean-Marc Collombet, Elise Four, Marie-France Burckhart, Catherine Masqueliez, Denis Bernabé, Dominique Baubichon, Francis Hérodin, Guy Lallement,