کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9034910 | 1132656 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Apoptosis induced by one new podophyllotoxin glucoside in human carcinoma cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Apoptosis induced by one new podophyllotoxin glucoside in human carcinoma cells Apoptosis induced by one new podophyllotoxin glucoside in human carcinoma cells](/preview/png/9034910.png)
چکیده انگلیسی
4-Demethyl-picropodophyllotoxin 7â²-O-β-d-glucopyranoside (4DPG), a new podophyllotoxin glucoside, was isolated from the rhizomes of Sinopodophyllum emodi (Wall.) Ying and showed cytotoxic effects in human carcinoma cells. Among the target cells (HeLa, A2 and SH-SY5Y), the cytotoxic effects of 4DPG showed dose- and time-dependency. Furthermore, the cervical carcinoma cell line, HeLa, was more sensitive to 4DPG. Flow cytometric analysis demonstrated the presence of apoptotic cells with low DNA content, a decrease of cell population at the G1 phase, and a concomitant increase of cell population at the G2/M phase. 4DPG also caused DNA fragmentation in HeLa cells. Treatment with 0.1 μM 4DPG increased p53 expression and Bax/Bcl-2 ratio in HeLa cells, as well as in A2 cells. These results suggested that 4DPG-induced apoptosis might be through a p53-dependent pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 212, Issue 1, 15 August 2005, Pages 46-53
Journal: Toxicology - Volume 212, Issue 1, 15 August 2005, Pages 46-53
نویسندگان
Qiu-Ying Zhang, Min Jiang, Chang-Qi Zhao, Miao Yu, Hui Zhang, Yu-jia Ding, Yong-Gong Zhai,