کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9093393 | 1149498 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Severe Irinotecan-Induced Toxicities in a Patient with Uridine Diphosphate Glucuronosyltransferase 1A1 Polymorphism
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Severe Irinotecan-Induced Toxicities in a Patient with Uridine Diphosphate Glucuronosyltransferase 1A1 Polymorphism Severe Irinotecan-Induced Toxicities in a Patient with Uridine Diphosphate Glucuronosyltransferase 1A1 Polymorphism](/preview/png/9093393.png)
چکیده انگلیسی
Irinotecan is an analogue of camptothecin, a topoisomerase I inhibitor, that has an important role in the management of advanced colorectal cancer. It is approved as first-line therapy in combination with 5-fluorouracil and leucovorin or as monotherapy in the second-line setting. Its clinical use has been associated with variability in terms of pharmacokinetic behavior and toxicities, especially myelosuppression and diarrhea. Irinotecan is metabolized to the active compound SN-38; it is now known that the metabolism of irinotecan and the inactivation of SN-38 by glucuronidation are mediated by genetic differences, which contributes to the variability. In this article, a case is presented that illustrates this, and there is a brief discussion of the clinical pharmacology of irinotecan and some of the genetic variations that affect its cellular metabolism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Colorectal Cancer - Volume 5, Issue 1, May 2005, Pages 61-64
Journal: Clinical Colorectal Cancer - Volume 5, Issue 1, May 2005, Pages 61-64
نویسندگان
Ranee Mehra, John Murren, Gina Chung, Brian Smith, Amanda Psyrri,