Assessment of Infusional 5-Fluorouracil Schedule and Dose Intensity: A Southwest Oncology Group and Eastern Cooperative Oncology Group Study

Increasing 5-FU dose intensity yields no survival advantage beyond that achieved with LDCI 5-FU. This study confirms the favorable toxicity profile of infusional 5-FU. Because no preferential benefit was observed for either infusion schedule, the more convenient weekly schedule should be considered for 5-FU-based combination regimens for disseminated CRC.