کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9093759 1149566 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
SU11248 and AG013736: Current Data and Future Trials in Renal Cell Carcinoma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
SU11248 and AG013736: Current Data and Future Trials in Renal Cell Carcinoma
چکیده انگلیسی
Several molecular pathways are implicated in renal cell carcinoma (RCC) pathogenesis, including the von Hippel-Lindau gene inactivation leading to vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) expression. SU11248 and AG013736 are small-molecule inhibitors of the tyrosine kinase portion of the VEGF and PDGF receptors. Substantial clinical activity has been reported for these agents in metastatic RCC trials, leading to additional investigations in a variety of settings.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Genitourinary Cancer - Volume 4, Issue 3, December 2005, Pages 175-180
نویسندگان
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