Neurotoxicity of Intrathecally Administered Bupivacaine Involves the Posterior Roots/Posterior White Matter and Is Milder Than Lidocaine in Rats

The neurotoxic lesions caused by bupivacaine and lidocaine were indistinguishable in the primary site and the extending pattern, such as axonal degeneration originating from the posterior roots and extending to the posterior white matter. The intrathecal neurotoxicity is greater in lidocaine than in bupivacaine.