کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9104800 | 1153393 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Local application of rhTGF-β2 enhances peri-implant bone volume and bone-implant contact in a rat model
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
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چکیده انگلیسی
Orthopedic and dental implant fixation depends upon bone regeneration. Growth factors such as transforming growth factor-beta (TGF-β) have been shown to enhance bone repair and strengthen the mechanical connection between implant and host skeleton in canine models. To provide a platform for studying molecular mechanisms of growth factor stimulated bone regeneration and implant fixation, the present study examined peri-implant bone volume as a response to TGF-β treatment in a rodent model. The rat femoral ablation model in which an implant is placed in the medullary cavity of the femur was used to examine the dose response to TGF-β2 applied to the implant (0, 0.1, 1.0, or 10 μg). The study included a total of 40 rats (10 per dose) examined at 28 days. Peri-implant bone volume and bone-implant contact were assessed through microcomputed tomography and implant fixation strength was determined by a mechanical pullout test. Treatment of the implant with 10 μg TGF-β2 led to a 2-fold increase in bone volume (P < 0.001) and a 1.5-fold increase in bone-implant contact (P < 0.01) with a trend of increasing fixation strength (non-significant increase of 1.4-fold). TGF-β2 treatment with 10 μg led to uniform peri-implant bone volume and bone-implant contact along the length of the implant, whereas the other groups had less bone at the mid-point compared to the proximal and distal aspects of the implant. About 50% of the variance in implant fixation strength was explained by a regression model involving both bone-implant contact and peri-implant bone volume.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 37, Issue 1, July 2005, Pages 55-62
Journal: Bone - Volume 37, Issue 1, July 2005, Pages 55-62
نویسندگان
Aladino De Ranieri, Amarjit S. Virdi, Shinji Kuroda, Susan Shott, Robert M. Leven, Nadim J. Hallab, Dale R. Sumner,