کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9110793 | 1155366 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immune-regulation of the apolipoprotein A-I/C-III/A-IV gene cluster in experimental inflammation
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کلمات کلیدی
VLDL-CHDL-CCETPLDL-CApr - آوریلapo - آپوApolipoprotein A-I - آپولیپوپروتئین A-IApolipoprotein A-IV - آپولیپوپروتئین A-IVApolipoprotein C-III - آپولیپوپروتئین C-IIIinflammation - التهاب( توروم) interleukin - اینترلوکینTriglycerides - تریگلیسریدtumor necrosis factor α - تومور نکروز عامل αPig - خوکCytokines - سیتوکین هاTNF-α - فاکتور نکروز توموری آلفاAcute-phase response - پاسخ فاز حادcholesterol ester transfer protein - پروتئین انتقال پروتئین کلسترول استC-reactive protein - پروتئین واکنشی سیCRP - پروتئین واکنشی سی یا سی. آر. پی total cholesterol - کلسترول تامhigh density lipoprotein cholesterol - کلسترول لیپوپروتئین با چگالی بالاlow density lipoprotein cholesterol - کلسترول لیپوپروتئین با چگالی کمVery low density lipoprotein cholesterol - کلسترول لیپوپروتئین با چگالی کم
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Apolipoprotein A-IV is a member of the apo A-I/C-III/A-IV gene cluster. In order to investigate its hypothetical coordinated regulation, an acute phase was induced in pigs by turpentine oil injection. The hepatic expression of the gene cluster as well as the plasma levels of apolipoproteins were monitored at different time periods. Furthermore, the involvement of the inflammatory mediators' interleukins 1 and 6 and tumor necrosis factor in the regulation of this gene cluster was tested in cultured pig hepatocytes, incubated with those mediators and apo A-I/C-III/A-IV gene cluster expression at the mRNA level was measured. In response to turpentine oil-induced inflammation, a decreased hepatic apo A-IV mRNA expression was observed (independent of apo A-I and apo C-III mRNA) not correlating with the plasma protein levels. The distribution of plasma apo A-IV experienced a shift from HDL to larger particles. In contrast, the changes in apo A-I and apo C-III mRNA were reflected in their corresponding plasma levels. Addition of cytokines to cultured pig hepatocytes also decreased apo A-IV and apo A-I mRNA levels. All these results show that the down-regulation of apolipoprotein A-I and A-IV messages in the liver may be mediated by interleukin 6 and TNF-α. The well-known HDL decrease found in many different acute-phase responses also appears in the pig due to the decreased expression of apolipoprotein A-I and the enlargement of the apolipoprotein A-IV-containing HDL.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 31, Issue 1, 7 July 2005, Pages 52-63
Journal: Cytokine - Volume 31, Issue 1, 7 July 2005, Pages 52-63
نویسندگان
MarÃa A. Navarro, Rakel Carpintero, Sergio AcÃn, Jose Miguel Arbonés-Mainar, LucÃa Calleja, Ricardo Carnicer, JoaquÃn C. Surra, Mario A. Guzmán-GarcÃa, Nieves González-Ramón, MarÃa Iturralde, FermÃn Lampreave, Andrés Piñeiro, Jesús Osada,