کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9111945 1568809 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Normocytic normochromic anemia due to autonomic neuropathy in type 2 diabetic patients without severe nephropathy
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Normocytic normochromic anemia due to autonomic neuropathy in type 2 diabetic patients without severe nephropathy
چکیده انگلیسی
We describe here four male patients with long-term and poorly controlled type 2 diabetes mellitus. They shared many common characteristic complications, such as severe autonomic neuropathy, proliferative retinopathy and normocytic normochromic anemia without progressive renal failure and macroangiopathy. They also showed normal levels of erythropoietin and reticulocyte, which was considered relatively low. The coefficient of variation of R-R, a useful method to estimate autonomic failure, showed markedly advanced autonomic neuropathy in all four patients. Coronary angiography did not reveal stenosis, anomaly or collateral vessels, but left ventriclography showed diffuse or partial hypokinesis. Massive proteinuria, high urinary levels of N-acetyl-β-d-glucosamidase (NAG) and β2-microglobulin (β2M) were detected, though creatinine clearance (Ccr) was not so deteriorated. Treatment with recombinant erythropoietin increased their hemoglobin and hematocrit levels. These common points have a possibility to be brought about by tubulointerstitial damage and microangiopathy may be involved in it.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes Research and Clinical Practice - Volume 70, Issue 3, December 2005, Pages 239-247
نویسندگان
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