کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9113194 | 1568935 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Developmental role of GnRH and PACAP in a zebrafish model
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Developmental role of GnRH and PACAP in a zebrafish model Developmental role of GnRH and PACAP in a zebrafish model](/preview/png/9113194.png)
چکیده انگلیسی
GnRH is expressed early in development long before reproduction begins. To determine whether GnRH has a role in development, gene knockdown with morpholinos was used in one-cell zebrafish embryos to block translation of gnrh mRNA into protein. Gene knockdown of gnrh2, gnrh3 or both at the one-cell stage resulted in a high percentage of embryos at 24-48Â h with a defective mid-hindbrain boundary and underdeveloped eyes; a small percentage of embryos at 72Â h had a defective heart. In similar studies on GHRH-PACAP, gene knockdown resulted in a smaller brain and eyes, but a normal-appearing heart. The evidence supports a role for the three neuropeptides in early development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: General and Comparative Endocrinology - Volume 142, Issues 1â2, 15 May 2005, Pages 74-80
Journal: General and Comparative Endocrinology - Volume 142, Issues 1â2, 15 May 2005, Pages 74-80
نویسندگان
Nancy M. Sherwood, Sheng Wu,