کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9119066 | 1158097 | 2005 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Systemic inflammation and weight gain in underweight patients with advanced pulmonary disease
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Weight changes influence the prognosis in patients with chronic obstructive pulmonary disease. We studied the association between systemic inflammation and weight gain in underweight patients with advanced pulmonary disease. Apart from C3, no significant differences in immunologic parameters occurred at baseline when comparing those who gained more than 2 kg (n = 17) with those who gained less (n = 17). An acute phase response (C-reactive protein > 5 mg/L) was present in 71% of the underweight patients (n = 42) and 59% of the normal-weight patients (n = 29), and it was associated with increased serum concentrations of immunoglobulins (IgG, IgM), C3, interleukin (IL)-2 sRα, soluble tumor necrosis factor α receptor (sTNF-α RI) in the underweight patients and IL-2 sRα in the normal-weight patients. After intervention, there was a significant reduction in C-reactive protein in the underweight patients with a weight gain of more than 2 kg, compared with those with a smaller weight gain, and a decrease in IgG (â0.2 [â3.4 to 1.6] vs 1.3 [â5.4 to 3.6] g/L, P = .02) and IL-2 sRα (â415 [â324 to 301] vs 45 [â619 to 1300] pg/mL, P = .005]. Our results suggest that there is some normalization of the immune activity after dietary intervention and weight gain in underweight patients with advanced pulmonary disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition Research - Volume 25, Issue 2, February 2005, Pages 119-131
Journal: Nutrition Research - Volume 25, Issue 2, February 2005, Pages 119-131
نویسندگان
Liv Førli, Ove J. Mellbye, Ãystein Bjørtuft, Morten Vatn, Johan Kofstad, Jacob Boe,