کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9133494 1161409 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Detection of a single nucleotide polymorphism in the IL-6 promoter region of ancient nuclear DNA
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک بوم شناسی، تکامل، رفتار و سامانه شناسی
پیش نمایش صفحه اول مقاله
Detection of a single nucleotide polymorphism in the IL-6 promoter region of ancient nuclear DNA
چکیده انگلیسی
In the current study a method was developed to examine the G/C single nucleotide polymorphism (SNP) at position −174 in the IL-6 promoter from nuclear DNA samples isolated from human skeletal remains from Manitoba, Canada, dating to as early as 3500 years ago. The IL-6 (−174) SNP was detected in three ancient samples and determined, as expected, in three out of three to be homozygous G/G. The analysis of cytokine SNPs of ancient nuclear DNA may provide novel insights into the genetic basis of autoimmune diseases and the susceptibility/resistance to infectious agents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Infection, Genetics and Evolution - Volume 5, Issue 2, March 2005, Pages 117-122
نویسندگان
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