کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9137901 | 1162499 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Blood coagulation factors as inflammatory mediators
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کلمات کلیدی
LPSTNFTFPITLRLBPCTGFMCPMIPMAPK - MAPKinflammation - التهاب( توروم) Blood coagulation - انعقاد خونinterleukin - اینترلوکینEPR - تشدید پارامغناطیس الکترونPar - توسطToll-like receptor - تیالآرMIF - شهرTissue factor - عامل بافتmigration inhibition factor - عامل مهار مهاجرتConnective tissue growth factor - فاکتور رشد بافت همبندtumor necrosis factor - فاکتور نکروز تومورlipopolysaccharide - لیپوپلی ساکاریدTissue factor pathway inhibitor - مهار کننده پروتئین بافتیprotease activated receptor - پروتئاز گیرنده فعالmacrophage inflammatory protein - پروتئین التهابی ماکروفاژmonocyte chemoattractant protein - پروتئین شیمیایی monocyte chemoattractantLPS binding protein - پروتئین متصل LPSmitogen-activated protein kinase - پروتئین کیناز فعال با mitogen
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
After the first observations about blood coagulation by Hippocrates, it took until the early 1900s before the classic theory of blood coagulation was presented. As more and more other coagulation factors were discovered, the four-factor coagulation scheme became more complex, but better understood, leading to the current coagulation cascade. As during the last decade it turned out that coagulation factors might do more than just promoting (or inhibiting) blood coagulation, new scientific avenues were pursued focusing on coagulation-independent properties of individual coagulation factors. This led to the current understanding that coagulation factors, like tissue factor (TF), FVII, FX, and thrombin, are important players in inflammation, vascular development, angiogenesis, and tumorigenesis. However, the molecular mechanism by which coagulation factors exert their pleiotropic effects in pathophysiology remains one of the major challenges in the field. This overview presents current insight in how the main coagulation factors might induce inflammation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Blood Cells, Molecules, and Diseases - Volume 34, Issue 1, JanuaryâFebruary 2005, Pages 30-37
Journal: Blood Cells, Molecules, and Diseases - Volume 34, Issue 1, JanuaryâFebruary 2005, Pages 30-37
نویسندگان
Saskia H.H.F Schoenmakers, Pieter H. Reitsma, C. Arnold Spek,