کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9157835 | 1172469 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Repetitive hypoxia increases lipid loading in human macrophages-a potentially atherogenic effect
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کلمات کلیدی
HUVECICAMVCAMHMDMvascular cellular adhesion moleculeAtherosclerosis - آترواسکلروز(تصلب شریان)Sleep apnea - آپنه خوابobstructive sleep apnea - آپنه خواب انسدادیhuman monocyte-derived macrophage - انسان مونوسیت مشتق شدهOsa - بخشHuman umbilical vein endothelial cell - سلول اندوتلیالی ورید ناقل انسانیFoam cell - سلول فومLow-density lipoprotein - لیپوپروتئین کم چگالی یا الدیال LDL - لیپوپروتئین کم چگالی(کلسترول بد)intercellular adhesion molecule - مولکول چسبندگی بین سلولی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
Obstructive sleep apnea (OSA) is characterized by repetitive episodes of hypoxia and is associated with an increase in cardiovascular disease. We, therefore, investigated the effect of repetitive hypoxia on two key early events in atherogenesis; lipid loading in foam cells and monocyte adhesion to endothelial cells. Human macrophages were loaded with acetylated low-density lipoproteins. During lipid loading, the cells were exposed to 30 min cycles of 2%/21% oxygen or control (room air, 5% CO2 incubator). Human umbilical vein endothelial cells (HUVECs) were also exposed to 30 min cycles of repetitive hypoxia or control conditions and monocyte adhesion measured. Cell adhesion molecules E-selectin, ICAM-1 and VCAM-1 were measured by ELISA. Repetitive hypoxia increased cholesteryl ester uptake by macrophages (127 ± 5% compared to controls; p = 0.003). By contrast, monocyte adhesion to HUVECs and cell adhesion molecule expression were unchanged by exposure to repetitive hypoxia, compared to controls (p > 0.1). Repetitive hypoxia, at levels relevant to tissues such as the arterial wall, enhances lipid uptake into human macrophages. This may contribute to accelerated atherosclerosis in OSA patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 179, Issue 2, April 2005, Pages 255-259
Journal: Atherosclerosis - Volume 179, Issue 2, April 2005, Pages 255-259
نویسندگان
Jo-Dee L. Lattimore, Ian Wilcox, Shirley Nakhla, Matthias Langenfeld, Wendy Jessup, David S. Celermajer,