کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9161914 1173455 2005 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cysteinyl Leukotrienes in Allergic Inflammation
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Cysteinyl Leukotrienes in Allergic Inflammation
چکیده انگلیسی
Systemically bioavailable leukotriene receptor antagonists (LTRAs) can reduce the essential components of allergic inflammation in allergic rhinitis (AR) and asthma by blocking cysteinyl leukotriene (CysLT) activity, resulting in a wide range of clinical effects. CysLTs, mediators, and modulators in the pathophysiology of asthma and AR are a key target for therapy because they modulate production of hemopoietic progenitor cells, survival and recruitment of eosinophils to inflamed tissue, activity of cytokines and chemokines, quantity of exhaled NO, smooth-muscle contraction, and proliferation of fibroblasts. The mechanism of action of LTRAs leads to their effects on systemic allergic inflammatory processes
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chest - Volume 127, Issue 4, April 2005, Pages 1312-1326
نویسندگان
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