کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9176678 | 1180351 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Large Cell Carcinoma With Calcitonin and Vasoactive Intestinal Polypeptide-Associated Verner-Morrison Syndrome
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Large Cell Carcinoma With Calcitonin and Vasoactive Intestinal Polypeptide-Associated Verner-Morrison Syndrome Large Cell Carcinoma With Calcitonin and Vasoactive Intestinal Polypeptide-Associated Verner-Morrison Syndrome](/preview/png/9176678.png)
چکیده انگلیسی
Verner-Morrison syndrome, characterized by diarrhea, hypokalemia, and hypochlorhydria, is caused most commonly by vasoactive intestinal polypeptide-secreting islet cell tumors of the pancreas. Verner-Morrison syndrome has not been described as a paraneoplastic syndrome in non-small cell lung cancer. We describe a 38-year-old man with metastatic non-small cell lung cancer of large cell carcinoma with neuroendocrine differentiation who presented with bone metastasis and intractable secretory diarrhea that was unresponsive to pharmacological treatment, including octreotide. Laboratory evaluation indicated elevated serum calcitonin and vasoactive intestinal polypeptide levels. Chemotherapy resulted in a transient response in the patient's diarrhea and neuroendocrine markers. The patient did not respond to further therapy and died 5 months after onset of back pain. To our knowledge, this is the first published case of large cell carcinoma with neuroendocrine differentiation associated with treatmentresponsive paraneoplastic Verner-Morrison syndrome.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mayo Clinic Proceedings - Volume 80, Issue 1, January 2005, Pages 116-120
Journal: Mayo Clinic Proceedings - Volume 80, Issue 1, January 2005, Pages 116-120
نویسندگان
Keith W. MD, Cynthia MD, Marie-Christine MD, Terri J. MD, Charles MD,