کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9178207 1180762 2005 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Arterial hypertension and cardiovascular prognosis after successful repair of aortic coarctation: A clinical model for the study of vascular function
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Arterial hypertension and cardiovascular prognosis after successful repair of aortic coarctation: A clinical model for the study of vascular function
چکیده انگلیسی
Despite successful surgical repair, aortic coarctation is associated with unfavourable prognosis mainly due to cardiovascular disease. Late timing of repair and arterial hypertension represent adverse prognostic factors. Arterial hypertension can recur after coarctation repair, despite the absence of residual obstruction, with a prevalence of up to 45%. Furthermore, even subjects with normal blood pressure values at rest may show an abnormal blood pressure elevation during exercise and daily life activities. The pathophysiology of such abnormal blood pressure behaviour is unclear. Different mechanisms have been proposed: resetting of the renin-angiotensin system, neurological dysfunction and impaired vascular reactivity and/or elastic properties. Several studies have supported these hypotheses, although the suggestion of a causative role of vascular dysfunction persisting late after coarctation repair has recently become more popular. Further studies are needed to investigate this issue; this particular syndrome may represent an important study model for the understanding of systolic hypertension.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition, Metabolism and Cardiovascular Diseases - Volume 15, Issue 5, October 2005, Pages 382-394
نویسندگان
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