Serial changes in neutrophil-endothelial activation markers during the course of sepsis associated with disseminated intravascular coagulation

We found close relations among the neutrophil-endothelial cell interactions, DIC, and MODS in patients with sepsis, severe sepsis, and septic shock. The results indirectly confirm the concept that DIC can produce organ dysfunction and that DIC reflects an inflammatory disorder of the microvasculature.