کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9185581 | 1183224 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of atorvastatin upon platelet activation in hypercholesterolemia, evaluated by flow cymetry
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کلمات کلیدی
P-selectinHMG-CoACD62HDL-CCD63ADPLDL-CALT3-hydroxy-3-methylglutaryl-coenzyme A - 3-هیدروکسی-3-methylglutaryl-coenzyme AAtorvastatin - آتورواستاتینaspartate amino transferase - آسپارتات آمین ترانسفرازAST - آسپارتات ترانس آمینازAlanine Amino Transferase - آلانین آمینو ترانسفرازALP - آلکالن فسفاتازAlkaline phosphatase - آلکالین فسفاتاز یا فسفاتاز قلیاییbpm - بوقلمونThrombin - ترومبین یا فاکتور II body mass index - شاخص توده بدنBMI - شاخص توده بدنیbeats per minute - ضربان در دقیقهPhosphatidylserine - فسفاتیدیلسرینPlatelet activation - فعال سازی پلاکتFlow cytometry - فلوسیتومتریMonth - ماهHyperlipidemia - هیپرلیپیدمیtotal cholesterol - کلسترول تامcalcium ionophore A23187 - کلسیم یونوفور A23187non significant - کم اهمیتgrams - گرمglycoprotein IIb/IIIa - گلیکوپروتئین IIb / IIIa
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Hyperlipidemia is a well established risk factor for cardiovascular disease and atherothrombotic events, in which platelet activation also plays a significant role. However, very few studies have addressed platelet activation in hypercholesterolemia, the potential effect of lipid lowering drugs upon platelet hyperfunction, and the question of whether changes in the latter are correlated to normalization of plasma lipids. This study used whole blood flow cytometry to assess in vivo and in vitro platelet activation in a group of 33 patients with hypercholesterolemia, and also the ex vivo effect of atorvastatin (20 mg/day) upon such activation. A control group of 40 normolipidemic volunteers matched in terms of age, sex and added risk factors to the patient group was used. The results showed that hypercholesterolemic patients had in vivo a significantly greater percentage of GPIIb/IIIa- and phosphatidylserine-positive platelets compared with the control group (4.62±3.51% and 2.58±1.19% versus 2.73±1.08% and 1.54±0.68%, respectively). In vitro response of CD62 expression to thrombin was also greater in the patients than in the controls (92.51±6.00% versus 89.63±10.72%, p<0.05). Atorvastatin therapy normalized platelet hyperfunction in the patients studied and reduced GPIIb/IIIa response to ADP (from 82.65±6.43% to 75.84±4.89%, p<0.01). A significant correlation can be seen between such normalization and the decrease in plasma levels of total and LDL cholesterol.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thrombosis Research - Volume 115, Issue 4, 2005, Pages 263-270
Journal: Thrombosis Research - Volume 115, Issue 4, 2005, Pages 263-270
نویسندگان
Manuel Labiós, Marcial MartÃnez, Francisco Gabriel, Victoria Guiral, Elena MartÃnez, Justo Aznar,