کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9186475 | 1579589 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel pathway for LPS-induced afferent vagus nerve activation: Possible role of nodose ganglion
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کلمات کلیدی
LPSIL-1βImmune-to-brain communication - ارتباط ایمنی به مغزInterleukin-1β - اینترلوکین-1βlipopolysaccharide - لیپوپلی ساکاریدHPA axis - محور هیپوتالاموس-هیپوفیز-آدرنالhypothalamic–pituitary–adrenal axis - محور هیپوتالاموس-هیپوفیز-آدرنالNodose ganglion - گنگلیون بینیToll-like receptor 4 - گیرنده تله مانند 4
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Novel pathway for LPS-induced afferent vagus nerve activation: Possible role of nodose ganglion Novel pathway for LPS-induced afferent vagus nerve activation: Possible role of nodose ganglion](/preview/png/9186475.png)
چکیده انگلیسی
The afferent vagus nerve has been suggested to be an important component for transmitting peripheral immune signals to the brain. However, there is inconsistent evidence showing that subdiaphragmatic vagotomy did not inhibit the brain mediated behavioral and neural effects induced by the peripheral application of lipopolysaccharide (LPS). LPS triggers innate immune cells through Toll-like receptor 4 (TLR4). In the present study, we found that TLR4 mRNA and protein was expressed in the rat nodose ganglion. Thus, it is suggested that LPS could activate afferent vagus nerve at the level of nodose ganglion, which exists centrally from the subdiaphragmatic level of vagus nerve. The results could provide evidence for the novel pathway of LPS-induced afferent vagus nerve activation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autonomic Neuroscience - Volume 120, Issues 1â2, 15 June 2005, Pages 104-107
Journal: Autonomic Neuroscience - Volume 120, Issues 1â2, 15 June 2005, Pages 104-107
نویسندگان
Toru Hosoi, Yasunobu Okuma, Tadashi Matsuda, Yasuyuki Nomura,