Ventricular reflex interactions during transmural myocardial ischemia

These results indicate that reflex excitatory responses mediated by left ventricular receptors with sympathetic afferent fibers can be elicited in dogs with intact vagal afferents. These excitatory responses are most apparent during transmural myocardial ischemia. In dogs with inhibitory responses to coronary occlusion, activation of sympathetic afferents during transmural ischemia appears to attenuate reflex inhibitory responses mediated by left ventricular vagal afferents.