کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9194510 | 1580502 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Involvement of prostaglandins in an animal model of Shigella-related seizures
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
We investigated whether prostaglandins (PGs), proinflammatory mediators implicated in excitatory activity, are involved in Shigella-related seizures. Pretreatment with S. dysenteriae sonicate (2LD50) enhanced mice response to pentylenetetrazole-induced seizures, without increase of brain concentrations of PGE2, PGD2 or PGF2α. Preinjection of NS-398, an inhibitor of cyclooxygenase-2, before treatment with Shigella sonicate, had no effect on seizures. The anticonvulsive PGD2 increased after injection of 8 LD50 of Shigella sonicate, which did not enhance seizures (32 pg/mg vs 26 pg/ml, p = 0.0063). The findings indicate that PGs are not involved in the enhanced seizure response after exposure to Shigella. However, induction of PGD2 may play an inhibitory role.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 168, Issues 1â2, November 2005, Pages 34-39
Journal: Journal of Neuroimmunology - Volume 168, Issues 1â2, November 2005, Pages 34-39
نویسندگان
Yael Yuhas, Abraham Weizman, Alexey Vanichkin, Shai Ashkenazi,