کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9194546 1580509 2005 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ocular inflammation alters swelling and membrane characteristics of rat Müller glial cells
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Ocular inflammation alters swelling and membrane characteristics of rat Müller glial cells
چکیده انگلیسی
Ocular inflammation is a common cause of retinal edema that may involve swelling of Müller glial cells. In order to investigate whether endotoxin-induced ocular inflammation in rats alters the swelling and membrane characteristics of Müller cells, lipopolysaccharide (LPS; 0.5%) was intravitreally injected. At 3 and 7 days after treatment, hypotonic challenge induced swelling of Müller cell somata that was not observed in non-treated control eyes. Müller cells of LPS-treated eyes displayed a downregulation of inward K+ currents and upregulation of A-type K+ currents that was associated with a decreased expression of Kir4.1 protein in retinal slices. The data suggest that ocular inflammation induces alterations of both the swelling characteristics and the K+ channel expression of Müller cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 161, Issues 1–2, April 2005, Pages 145-154
نویسندگان
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