کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9194575 1580504 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Programmed cell death of myelin basic protein-specific T lymphocytes is reduced in patients with acute multiple sclerosis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Programmed cell death of myelin basic protein-specific T lymphocytes is reduced in patients with acute multiple sclerosis
چکیده انگلیسی
We investigated the apoptosis of myelin basic protein (MBP)-specific T lymphocytes in multiple sclerosis (MS) patients with acute (AMS) or stable (SMS) MS by evaluating the expression of apoptosis markers on peripheral cells. Cells of healthy controls (HC) were evaluated as well. Results showed that mitogen-stimulated apoptosis was comparable among patients and controls, whereas MBP-stimulated CD4+ and CD8+ 7-AAD+ and 7-AAD+ Fas+ cell (apoptotic cells) were significantly reduced in AMS patients. A reduction of the apoptotic rate of myelin-specific CD4+ and CD8+ T lymphocytes could be involved in the immune-mediated destruction of the myelin sheath seen in AMS patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 166, Issues 1–2, September 2005, Pages 173-179
نویسندگان
, , , , , , , , , , , ,