کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9194575 | 1580504 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Programmed cell death of myelin basic protein-specific T lymphocytes is reduced in patients with acute multiple sclerosis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
We investigated the apoptosis of myelin basic protein (MBP)-specific T lymphocytes in multiple sclerosis (MS) patients with acute (AMS) or stable (SMS) MS by evaluating the expression of apoptosis markers on peripheral cells. Cells of healthy controls (HC) were evaluated as well. Results showed that mitogen-stimulated apoptosis was comparable among patients and controls, whereas MBP-stimulated CD4+ and CD8+Â 7-AAD+ and 7-AAD+ Fas+ cell (apoptotic cells) were significantly reduced in AMS patients. A reduction of the apoptotic rate of myelin-specific CD4+ and CD8+Â T lymphocytes could be involved in the immune-mediated destruction of the myelin sheath seen in AMS patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 166, Issues 1â2, September 2005, Pages 173-179
Journal: Journal of Neuroimmunology - Volume 166, Issues 1â2, September 2005, Pages 173-179
نویسندگان
Marina Saresella, Ivana Marventano, Livianna Speciale, Stefania Ruzzante, Daria Trabattoni, Silvia Della Bella Silvia Della Bella, Massimo Filippi, Francesca Fasano, Rosella Cavarretta, Domenico Caputo, Mario Clerici, Pasquale Ferrante,