کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9194628 1580510 2005 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prolactin affects both survival and differentiation of T-cell progenitors
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Prolactin affects both survival and differentiation of T-cell progenitors
چکیده انگلیسی
We have analysed the in vitro effects of prolactin on thymocyte development concluding that PRL favours the survival and differentiation of T-cell progenitors. Fetal, adult thymocytes and CD45+ fetal liver lymphoid progenitors express PRL-R. PRL induces survival, proliferation and differentiation of lymphoid progenitors whereas both an anti-PRL antiserum and an anti-PRL-R mAb block T-cell development accumulating CD25+DN (CD4−CD8−) cells. Furthermore, IL2 rescues the blockade of T-cell development in FTOC treated with anti-PRL antiserum but PRL does not recover cultures treated with an anti-IL2R α chain mAb, which drastically blocks the T-cell development. These results support IL2/IL2R mediation of PRL effects on developing thymocytes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 160, Issues 1–2, March 2005, Pages 135-145
نویسندگان
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