کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9194659 | 1580508 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Autoantibodies against the amino terminal of α-enolase are a useful diagnostic marker of Hashimoto's encephalopathy
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
We investigated autoantibodies and their epitope(s) in Hashimoto's encephalopathy associated with Hashimoto's thyroiditis. In a proteomic analysis, they proved to recognize α-enolase. We further searched the epitope region in α-enolase using different regions of recombinant proteins expressed in cultured human cells. The amino terminal region was recognized by autobodies from a much higher proportion of patients with Hashimoto's encephalopathy (83.3%; 5/6) than from patients with Hashimoto's thyroiditis (11.8%; 2/17), and not at all by sera from controls (25 healthy individuals and 25 controls with other neurological disorders) (0%; 0/50). Neither the carboxyl terminal nor the mid-region of α-enolase showed specificity for Hashimoto's encephalopathy. Autoantibodies against the amino terminal of α-enolase are a useful diagnostic marker for Hashimoto's encephalopathy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 162, Issues 1â2, May 2005, Pages 130-136
Journal: Journal of Neuroimmunology - Volume 162, Issues 1â2, May 2005, Pages 130-136
نویسندگان
A. Fujii, M. Yoneda, T. Ito, O. Yamamura, S. Satomi, H. Higa, A. Kimura, M. Suzuki, M. Yamashita, T. Yuasa, H. Suzuki, M. Kuriyama,