کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9194687 | 1580507 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development of a rapid autopsy program for studies of brain immunity
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Human glia are essential cellular models used for studies of neurodegenerative diseases. Fetal neuroglia are commonly used, as they can be recovered in large quantities and sustained for long periods in culture. However, fetal neuroglia may have limitations in reflecting adult diseases and additionally can pose ethical issues in translating products of abortion for research use. To address these concerns, we developed a rapid autopsy program to procure age- and disease-specific neuroglia from adult brain tissues within hours of death. The challenges in developing this initiative, reflecting experiences from 69 autopsies over 4 years, are presented.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 163, Issues 1â2, June 2005, Pages 135-144
Journal: Journal of Neuroimmunology - Volume 163, Issues 1â2, June 2005, Pages 135-144
نویسندگان
Anuja Ghorpade, Leslie Bruch, Yuri Persidsky, Betty Chin, William H.C. Brown, Kathleen Borgmann, Raisa Persidsky, Li Wu, Spring Holter, Robin Cotter, Jill Faraci, David Heilman, VaKara Meyer, Jane F. Potter, Susan Swindells, Howard E. Gendelman,