کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9194690 | 1580507 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
We investigated the role of three polymorphisms in the IFNAR1 (SNPs 18417 and -408) and IFNAR2 (SNP 11876) genes in multiple sclerosis (MS) susceptibility and in the IFNβ treatment response in a group of 147 patients and 210 controls undergoing interferon therapy during the last 2 years. Only the 18417 and the 11876 SNPs showed an association with disease susceptibility (p = 0.001 and 0.035, respectively) although no differential genotype distribution were observed between interferon responders and non-responder MS patients. No alteration of the expression level of IFNAR-1 was observed with respect to the â408 genotypes or to interferon treatment response. These data suggest a role for the IFNAR pathway in susceptibility to MS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 163, Issues 1â2, June 2005, Pages 165-171
Journal: Journal of Neuroimmunology - Volume 163, Issues 1â2, June 2005, Pages 165-171
نویسندگان
Laura Leyva, Oscar Fernández, Maria Fedetz, Eva Blanco, Victoria E. Fernández, Begoña Oliver, Antonio León, Maria-Jesus Pinto-Medel, Cristobalina Mayorga, Miguel Guerrero, Gloria Luque, Antonio Alcina, Fuencisla Matesanz,