کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9194775 | 1580511 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CTLA-4 gene polymorphism is not associated with conventional multiple sclerosis in Japanese
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
We investigated the polymorphisms of exon 1 (+49A/G) and promoter (â318C/T and â651C/T) regions of the CTLA-4 gene in 133 Japanese patients with conventional/classical multiple sclerosis (MS) and 156 healthy controls. Patients with optico-spinal MS (OSMS) or atypical clinical attacks were excluded from the study. There was no significant difference in the distribution of polymorphisms between patients and controls. Furthermore, there were no associations between polymorphisms and clinical characteristics, such as age at onset, disease prognosis, and HLA profiles. Our results suggest that CTLA-4 gene polymorphisms are neither conclusively related to susceptibility nor to the clinical characteristics of MS, especially in Japanese patients with conventional/classical form and clinical features identical to those of their counterparts in Western countries.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 159, Issues 1â2, February 2005, Pages 225-229
Journal: Journal of Neuroimmunology - Volume 159, Issues 1â2, February 2005, Pages 225-229
نویسندگان
Toshiyuki Fukazawa, Seiji Kikuchi, Ryuji Miyagishi, Masaaki Niino, Ichiro Yabe, Takeshi Hamada, Hidenao Sasaki,