کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9194819 1580512 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ontogenesis and functional aspects of oxytocin and vasopressin gene expression in the thymus network
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Ontogenesis and functional aspects of oxytocin and vasopressin gene expression in the thymus network
چکیده انگلیسی
Ontogenesis of oxytocin (OT) and vasopressin (VP) gene expression and function were investigated in murine thymus. OT and VP transcripts were detected in the thymus on embryonic days 13 and 15, respectively. Corresponding messenger RNAs were evidenced in thymic epithelial cells by in situ hybridization with a neurophysin probe. From all OT and VP receptors, only OTR was expressed by all T-cell subsets, while V1bR was found in double positive and single positive CD8 cells. In fetal thymic organ cultures, OTR antagonist d[d-Tyr(Et)2, Thr4]OVT increased early apoptosis of CD8 cells, while V1bR antagonist (Sanofi SSR149415) inhibited T-cell differentiation, and favored CD8 T-cell commitment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 158, Issues 1–2, January 2005, Pages 67-75
نویسندگان
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