کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9197935 | 1188881 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Functional 1H-MRS findings in migraine patients with and without aura assessed interictally
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
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چکیده انگلیسی
The present study was aimed at investigating changes in brain metabolites due to visual cortex activation in migraineurs and normal subjects by 1H-magnetic resonance spectroscopy (MRS). Twenty-two migraine patients with aura, 22 migraine patients without aura, and 10 control subjects were assessed. The volume of interest (about 8 cm3) was placed on the visual cortex area and the visual stimulus was applied using MR-compatible goggles with a flashing red light at a frequency of 8 Hz and an intensity of 14 lx. Data were acquired over 36â²40ʺ. The experimental time course was: baseline phase, from 0 to 3â²40ʺ (1 spectrum); on phase (flashing light condition), from 3â²40ʺ to 29â²20ʺ (1540ʺ) (7 spectra), and off phase, from 29â²20ʺ to the end of the experiment at 36â²40ʺ (2 spectra). The main result of photic stimulation in patients with migraine with aura is the more consistent decrease (â14.61%) of the N-acetylaspartate (NAA) signal, which is significantly greater than that found in migraine patients without aura and control subjects. A parallel slight increase in the lactate peak was also detected. The above findings support little differences in brain metabolites between the two patient groups assessed in interictal periods, which suggests a less efficient mitochondrial functioning in migraine with aura patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 24, Issue 4, 15 February 2005, Pages 1025-1031
Journal: NeuroImage - Volume 24, Issue 4, 15 February 2005, Pages 1025-1031
نویسندگان
Paola Sarchielli, Roberto Tarducci, Otello Presciutti, Gianni Gobbi, Gian Piero Pelliccioli, Giuseppe Stipa, Andrea Alberti, Giuseppe Capocchi,