Conocimientos Actuales En La Fisiopatología De La Sepsis

Recent progress in molecular biology has made possible to identify the basic mechanisms by which bacterial components interact with the innate immune system to activate the inflammatory response. The recent identification of Tolllike receptors (TLRs) family (membrane receptors that interact with various agents as endotoxin, peptidoglycans, cellular detritus, and viral DNA) has explained the capacity of the host to respond to any challenge identified as extrinsic. The attempts to improve the prognosis of sepsis by blocking these mechanisms through antiinflammatory interventions have demonstrated in general a small and insignificant benefit.