کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9241763 | 1209244 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Is the Monocyte Chemotactic Protein-1 â2518 G Allele a Risk Factor for Severe Acute Pancreatitis?
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کلمات کلیدی
MCP-1APACHEmild acute pancreatitisSAP - شیرهconfidence interval - فاصله اطمینانAcute Physiology and Chronic Health Evaluation - فیزیولوژی حسی و ارزیابی سلامت مزمنodds ratio - نسبت شانس هاmap - نقشهAcute pancreatitis - پانکراتیت حادSevere acute pancreatitis - پانکراتیت حاد شدیدMonocyte chemotactic protein-1 - پروتئین chemotactic monocyte-1
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Background & Aims: Acute pancreatitis (AP) reflects the intensity of the inflammatory response and is divided into mild AP (MAP) or severe AP (SAP). Monocyte chemotactic protein-1 (MCP-1) gene expression is altered by an A/G polymorphism (â2518), with the G allele increasing MCP-1 production. Our aim was to determine whether the MCP-1 â2518 A/G polymorphism affects the severity of AP. Methods: Seventy-seven consecutive patients and 116 controls were evaluated. The A/G genotype was evaluated by polymerase chain reaction amplification, restriction fragment length polymorphism, and DNA sequencing. MCP-1 serum levels were quantified using a fluorescence bead-based immunoassay. Results: Sixty-three of 77 patients had MAP (82%) and 14 of 77 had SAP (18%). Patients with SAP had a significantly greater proportion of the G allele (12 of 14; 86%) than did control subjects (50 of 116; 43%) (odds ratio [OR], 7.9; 95% confidence interval [CI], 1.7-37, P < .003) or MAP patients (29 of 63; 46%) (OR, 7.0; 95% CI, 1.5-34; P < .007). Patients with pancreatitis and AA genotype had a low risk for SAP (OR, .13; 95% CI, .01-.61; P < .003). As predicted by the genotype, the serum MCP-1 levels were significantly higher in the SAP patients when compared with the MAP patients (P = .002) and they also predicted death. Conclusions: MCP-1 â2518 G allele is a risk factor for severe AP. MCP-1 serum levels, measured early in the course of AP, appear to be an accurate predictor of severity of acute pancreatitis and death.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Gastroenterology and Hepatology - Volume 3, Issue 5, May 2005, Pages 475-481
Journal: Clinical Gastroenterology and Hepatology - Volume 3, Issue 5, May 2005, Pages 475-481
نویسندگان
Georgios I. Papachristou, David A. Sass, Haritha Avula, Janette Lamb, Anna Lokshin, M. Michael Barmada, Adam Slivka, David C. Whitcomb,