کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9245466 | 1209948 | 2005 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Duodenal ulcer promoting gene of Helicobacter pylori
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
CREBcitrate-phosphate bufferCREBHICPBISREAP-1CRE binding protein - CRE پروتئین اتصالMOI - MEinterleukin - اینترلوکینPAI - باباbrain heart infusion - تزریق قلب مغزیELISA - تست الیزاEnzyme-linked immunosorbent assay - تست الیزاPathogenicity island - جزیره پاتوژنیکduodenal ulcer - زخم دوازدههGastric ulcer - زخم معدهnuclear factor - عامل هسته ایcAMP responsive element - عنصر پاسخگو cAMPpolymerase chain reaction - واکنش زنجیره ای پلیمرازPCR - واکنش زنجیرهٔ پلیمرازactivator protein-1 - پروتئین فعال کننده-1multiplicity of infection - چندین عفونت
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Background & Aims: Identification of a disease-specific H pylori virulence factors predictive of the outcome of infection remains unachieved. Methods: We used the polymerase chain reaction and Southern blot to compare the presence of 14 vir homologue genes with clinical presentation of H pylori infection, mucosal histology, and mucosal interleukin (IL)-8 levels. Results: We examined 500 H pylori strains from East Asia and South America, including 120 with gastritis, 140 with duodenal ulcer (DU), 110 with gastric ulcer (GU), and 130 with gastric cancer. Only 1 gene that encompassed both jhp0917 and jhp0918 called dupA (duodenal ulcer promoting gene) was associated with a specific clinical outcome. dupA was present in 42% of DU vs. 21% of gastritis (adjusted odds ratio [OR] = 3.1, 95% confidence interval [CI]: 1.7-5.7). Its presence was also associated with more intense antral neutrophil infiltration and IL-8 levels and was a marker for protection against gastric atrophy, intestinal metaplasia, and gastric cancer (OR for gastric cancer = 0.42, 95% CI: 0.2-0.9 compared with gastritis). In vitro studies in gastric epithelial cells using dupA-deleted and -complemented mutants showed that the dupA plays roles in IL-8 production, in activation of transcription factors responsible for IL-8 promoter activity, and in increased survivability at low pH. Conclusions:dupA is a novel marker associated with an increased risk for DU and reduced risk for gastric atrophy and cancer. Its association with DU-promoting and -protective effects against atrophy/cancer was evident in both Asian and Western countries.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 128, Issue 4, April 2005, Pages 833-848
Journal: Gastroenterology - Volume 128, Issue 4, April 2005, Pages 833-848
نویسندگان
Hong Lu, Ping-I. Hsu, David Y. Graham, Yoshio Yamaoka,