کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9245490 | 1209948 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Therapeutic effects of rectal administration of basic fibroblast growth factor on experimental murine colitis
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کلمات کلیدی
EGFTNFMuc2TNBSMLNKGFTGFITFPPARFGFbFGFDSSCOXcyclooxygenase - آنزیم سیکلواکسیژنازTrinitrobenzene sulfonic acid - اسید سولفونیک Trinitrobenzeneinterleukin - اینترلوکینtransforming growth factor - تبدیل فاکتور رشدDextran sulfate sodium - سولفات سدیم دکسترانintestinal trefoil factor - عامل تراوش رودهepidermal growth factor - عامل رشد اپیدرمیKeratinocyte growth factor - عامل رشد کراتینوسیتVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)fibroblast growth factor - فاکتور رشد فیبروبلاستbasic fibroblast growth factor - فاکتور رشد فیبروبلاست پایهtumor necrosis factor - فاکتور نکروز تومورMucin 2 - موین 2polymerase chain reaction - واکنش زنجیره ای پلیمرازPCR - واکنش زنجیرهٔ پلیمرازmesenteric lymph nodes - گره های لنفاوی مزانتریکperoxisome proliferator-activated receptor - گیرنده فعال فعال پروکسیوم
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Therapeutic effects of rectal administration of basic fibroblast growth factor on experimental murine colitis Therapeutic effects of rectal administration of basic fibroblast growth factor on experimental murine colitis](/preview/png/9245490.png)
چکیده انگلیسی
Background & Aims: Basic fibroblast growth factor (bFGF) is a promising therapeutic agent for various diseases. It remains unclear, however, whether bFGF is effective for the treatment of inflammatory bowel disease. The aim of this study was to examine the efficacy of bFGF on 2 experimental murine colitis models and to investigate its molecular mechanisms. Methods: We evaluated the effects of human recombinant bFGF (hrbFGF) on mice with dextran sulfate sodium (DSS)-induced colitis and mice with trinitrobenzene sulfonic acid (TNBS)-induced colitis as well as normal mice. Body weight, survival rate, and histologic findings of the colonic tissues were examined. Gene expression of tumor necrosis factor (TNF)-α, cyclooxygenase (COX)-2, transforming growth factor (TGF)-β, mucin 2 (MUC2), intestinal trefoil factor (ITF), and vascular endothelial growth factor (VEGF) in the colonic tissues was determined. The proliferation activity of hrbFGF on the colonic epithelium was evaluated by immunohistochemistry. Results: Rectal administration of hrbFGF ameliorated DSS-induced colitis in a dose-dependent manner. Gene expression of TNF-α was significantly reduced in the colonic tissues of mice with DSS-induced colitis treated with hrbFGF, whereas MUC2 and ITF messenger RNA expression was up-regulated. Rectal administration of hrbFGF significantly improved the survival rate of mice with TNBS-induced colitis and partially ameliorated colitis. hrbFGF significantly increased the number of Ki-67-positive cells in the colonic epithelium of normal mice, and up-regulated the gene expression of COX-2, TGF-β, MUC2, ITF, and VEGF in the colonic tissues. Conclusions: Rectal administration of bFGF might be a promising option for the treatment of inflammatory bowel disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 128, Issue 4, April 2005, Pages 975-986
Journal: Gastroenterology - Volume 128, Issue 4, April 2005, Pages 975-986
نویسندگان
Minoru Matsuura, Kazuichi Okazaki, Akiyoshi Nishio, Hiroshi Nakase, Hiroyuki Tamaki, Kazushige Uchida, Toshiki Nishi, Masanori Asada, Kimio Kawasaki, Toshiro Fukui, Hazuki Yoshizawa, Shinya Ohashi, Satoko Inoue, Chiharu Kawanami, Hiroshi Hiai,