کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9245592 | 1209949 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Amphiregulin: An early trigger of liver regeneration in mice
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کلمات کلیدی
TNFTGFEGF-RFCSHB-EGFHGFPGE2ERKPI-3KCREJnkWT1PCNAEGF5-bromo-2′-deoxyuridine - 5-bromo-2'-deoxyuridinep38 MAPK - P38 MAPKamphiregulin - آمفیرگولینProliferating Cell Nuclear Antigen - آنتیژن هسته ای تکثیر سلولیinterleukin - اینترلوکینBrdU - بروموداکسی اوریدینtransforming growth factor - تبدیل فاکتور رشدfetal calf serum - سرم گوساله جنینepidermal growth factor - عامل رشد اپیدرمیHepatocyte growth factor - عامل رشد هپاتوسیتHeparin-binding EGF-like growth factor - فاکتور رشد مانند EGF مانند هپارینtumor necrosis factor - فاکتور نکروز تومورPhosphatidylinositol 3-kinase - فسفاتیدیلینواستیل 3-کینازMEK - مجاهدین خلقPartial hepatectomy - هپاتکتومی جزئیpolymerase chain reaction - واکنش زنجیره ای پلیمرازPCR - واکنش زنجیرهٔ پلیمرازp38 mitogen-activated protein kinase - پروتئین کیناز متیوژن فعال p38Prostaglandin E2 - پروستاگلاندین E2extracellular regulated kinase - کیناز تنظیم شده خارج سلولیEpidermal growth factor receptor - گیرنده فاکتور رشد اپیدرمال
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Background & Aims: Liver regeneration is a unique response directed to restore liver mass after resection or injury. The survival and proliferative signals triggered during this process are conveyed by a complex network of cytokines and growth factors acting in an orderly manner. Activation of the epidermal growth factor receptor is thought to play an important role in liver regeneration. Amphiregulin is a member of the epidermal growth factor family whose expression is not detectable in healthy liver. We have investigated the expression of amphiregulin in liver injury and its role during liver regeneration after partial hepatectomy. Methods: Amphiregulin gene expression was examined in healthy and cirrhotic human and rat liver, in rodent liver regeneration after partial hepatectomy, and in primary hepatocytes. The proliferative effects and intracellular signaling of amphiregulin were studied in isolated hepatocytes. The in vivo role of amphiregulin in liver regeneration after partial hepatectomy was analyzed in amphiregulin-null mice. Results: Amphiregulin gene expression is detected in chronically injured human and rat liver and is rapidly induced after partial hepatectomy in rodents. Amphiregulin expression is induced in isolated hepatocytes by interleukin 1β and prostaglandin E2, but not by hepatocyte growth factor, interleukin 6, or tumor necrosis factor α. We show that amphiregulin behaves as a primary mitogen for isolated hepatocytes, acting through the epidermal growth factor receptor. Finally, amphiregulin-null mice display impaired proliferative responses after partial liver resection. Conclusions: Our findings indicate that amphiregulin is an early-response growth factor that may contribute to the initial phases of liver regeneration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 128, Issue 2, February 2005, Pages 424-432
Journal: Gastroenterology - Volume 128, Issue 2, February 2005, Pages 424-432
نویسندگان
Carmen Berasain, Elena R. GarcÃa-Trevijano, Josefa Castillo, Elena Erroba, David C. Lee, Jesús Prieto, MatÃas A. Avila,