کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
924741 921264 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Domain or not domain? That is the question: Longitudinal semantic deterioration in Alzheimer’s disease
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
Domain or not domain? That is the question: Longitudinal semantic deterioration in Alzheimer’s disease
چکیده انگلیسی

Category specific semantic impairment (e.g. living versus nonliving things) has been reported in association with various pathologies, including herpes simplex encephalitis and semantic dementia. However, evidence is inconsistent regarding whether this effect exists in diseases progressively impacting diverse cortical regions, such as Alzheimer’s disease (AD). Ceiling effects producing non-Gaussian distributions and poor control for confounds such as nuisance variables (e.g. familiarity) may contribute to this discrepancy. Fourteen AD patients were longitudinally studied examining category effects on three semantic tasks (picture naming, naming to description and word to picture matching) matched across domain on all known nuisance variables (NV). To address non-Gaussian distributions, we run bootstrap analyses to determine whether NV, semantic domain or control performance best predicted AD patient performance. Multiple hierarchical regression analyses revealed that, whilst NV accounted for most of the explained variance in patients in the three tasks, the influence of semantic domain was substantially lower. Individual logistic regression demonstrated a significant category effect in only a few patients and healthy controls. No significant qualitative changes were observed in patients over time. Our results confirm the importance of NVs as predictors of AD patient performance, suggesting that the role of semantic domain is not a useful predictor of the progressive deterioration in AD.


► Category-specificity was longitudinally studied in 14 Alzheimer’s disease patients.
► Semantic domain accounted for less variance than nuisance variables.
► Category effects were found in few individuals, and were not specific to patients.
► No qualitative semantic impairment changes were observed longitudinally.
► Semantic domain is not a useful predictor of the progressive deterioration in AD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain and Cognition - Volume 77, Issue 1, October 2011, Pages 89–95
نویسندگان
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