کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9252872 | 1210880 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lessons from large-scale gene profiling of the liver in alcoholic liver disease
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This review examines the studies pertaining to large-scale gene profiling of liver cells and the whole liver as performed with the aid of macro- or microarray gene detection technology under the conditions of alcohol-induced liver injury. The review emphasizes the variability of the data as a function of strain, species, and model of alcohol-induced liver injury employed in different studies. Further, the review highlights the importance of determining if changes in transcriptome expression are parallelled by changes in proteome and metabolome of the liver. On the basis of such data, models can be constructed to unravel new mechanistic aspects of alcohol-induced liver injury and to design novel therapies for alcoholic liver disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hepatology Research - Volume 31, Issue 4, April 2005, Pages 187-192
Journal: Hepatology Research - Volume 31, Issue 4, April 2005, Pages 187-192
نویسندگان
Ion V. Deaciuc, Zhenyuan Song, Craig J. McClain,