کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9252877 | 1210880 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Efficacy of prolonged treatment following combination with ribavirin and interferon for chronic hepatitis type C: A pilot study
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Efficacy of prolonged treatment following combination with ribavirin and interferon for chronic hepatitis type C: A pilot study Efficacy of prolonged treatment following combination with ribavirin and interferon for chronic hepatitis type C: A pilot study](/preview/png/9252877.png)
چکیده انگلیسی
The aim of the present study was to assess the efficacy of the prolonged interferon monotherapy following combination treatment. Seventy-six patients were enrolled. Of these, 7 were withdrawn while undergoing treatment with interferon combined with ribavirin, and 12 remained positive for HCV-RNA at the completion of the combination treatment. We studied 57 Japanese patients with chronic hepatitis C due to genotype 1b HCV of a high viral load. These patients tested negative for HCV-RNA at the completion of the combination treatment for 24 weeks. After the combination treatment, 29 patients of the prolonged treatment group successively received interferon-α monotherapy for 24 weeks, while 28 patients in the combination treatment alone group received no medication. The rate of a sustained virologic response (SVR) was higher in the prolonged treatment group (41%, 12/29) than in the combination treatment alone group (25%, 7/28), but not significantly. Patients who became HCV-RNA negative by 4 weeks after the start of the combination treatment showed an SVR rate of 86%. The prolonged treatment resulted in SVR in all five patients who newly became HCV-RNA negative at 12 weeks. In conclusion, the prolonged treatment was effective for patients who newly became HCV-RNA negative at 12 weeks.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hepatology Research - Volume 31, Issue 4, April 2005, Pages 211-216
Journal: Hepatology Research - Volume 31, Issue 4, April 2005, Pages 211-216
نویسندگان
Hideyuki Nomura, Yoichiro Kashiwagi, Hisashi Nakashima, Hironori Tanimoto, Junya Shimono, Eiji Kajiwara, Toshihiro Maruyama, Nobuyuki Yamashita, Masanori Nagano, Masashi Higashi, Tamotsu Mukai, Yutaka Matsui, Jun Hayashi, Seizaburo Kashiwagi,