کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9252893 | 1210881 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Efficacy of ribavirin monotherapy following combination therapy with interferon alfa-2b and ribavirin for patients with chronic hepatitis C
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کلمات کلیدی
SVRALTAlanine aminotransferase - آلانین آمینوترانسفرازRNA - اسید ریبونوکلئیکribonucleic acid - اسید ریبونوکلئیکinterferon - اینترفرونInterferon alfa - اینترفرون آلفاIFN - اینترفرون هاRibavirin - ریباویرین million units - میلیون واحدchronic hepatitis C - هپاتیت C مزمنHCV - هپاتیت سیHepatitis C virus - هپاتیت سیHIV - ویروس نقص ایمنی انسانی human immunodeficiency virus - ویروس نقص ایمنی انسانیSustained viral response - پاسخ ویروسی پایدار
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Reappearance of HCV-RNA followed by exacerbation of biochemical parameters after combination therapy consisting of interferon and ribavirin is an obstacle to achieve sustained response and improve long-term prognosis. We hypothesed that ribavirin monotherapy after 6 months of combination therapy may improve sustained viral and biochemical responses, and conducted a prospective, randomized and controlled study. Thirty-eight patients with chronic hepatitis C treated with combination therapy for 6 months and had no detectable serum HCV-RNA were enrolled, and allocated into two arms. Group I (n = 19) was continuously administered oral ribavirin for additional 6 months, and group II (n = 19) was followed up without any further treatment. At the end of trial, HCV-RNA negativity was 11/19 (58%) in group I, and 6/19 (32%) in group II (p = 0.191). Multivariant analysis demonstrated that ribavirin monotherapy was not a predictor for the eradication of HCV-RNA. In cases without sustained viral responses, serum ALT levels at baseline and the end of 48 weeks' trial were 54.6 and 44.4 in group I (p = 0.237), and significant reduction with ribavirin monotherapy was not observed. In conclusion, ribavirin monotherapy following combination therapy fails to improve sustained viral response as well as biochemical response.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hepatology Research - Volume 32, Issue 2, June 2005, Pages 101-106
Journal: Hepatology Research - Volume 32, Issue 2, June 2005, Pages 101-106
نویسندگان
Ryozo Nagayama, Atsushi Tanaka, Haruhiro Ankoh, Tohru Narita, Masaki Izumi, Kazuhiko Miyake, Hajime Takikawa,