کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9261655 1214314 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immuno-tolerogenic functions of HLA-G: Relevance in transplantation and oncology
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Immuno-tolerogenic functions of HLA-G: Relevance in transplantation and oncology
چکیده انگلیسی
Over the past few years, the non-classical HLA class I molecule HLA-G has been the center of intense investigations that have led to the description of its particular structural and functional properties. Although located in the HLA class I region of chromosome six, the HLA-G gene may be distinguished from other HLA class I genes by its low polymorphism and alternative splicing that generates seven HLA-G proteins, whose tissue-distribution is restricted to normal fetal and adult tissues that display a tolerogeneic function towards both innate and acquired immune cells. We review here the functions of HLA-G from an immunological stand point, focusing on the recent advances in this field and on their potential impact in human pathologies, such as cancer and organ transplantation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autoimmunity Reviews - Volume 4, Issue 8, November 2005, Pages 503-509
نویسندگان
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