کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9261925 | 1214438 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
What do antineutrophil cytoplasmic antibodies (ANCA) tell us?
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کلمات کلیدی
Small-vessel vasculitisdirect ELISAmicroscopic polyangiitis - polyangiitis میکروسکوپیAntineutrophil cytoplasmic antibodies (ANCA) - آنتی تروپلاستمی ضد آنتیبادی (ANCA)Indirect immunofluorescence - ایمونوفلورسانس غیر مستقیمCapture ELISA - ضبط الیزاmyeloperoxidase - میلوپراکسیداز proteinase 3 - پروتئیناز 3Wegener's granulomatosis - گرانولوماتوز Wegener
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
ایمونولوژی، آلرژی و روماتولوژی
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چکیده انگلیسی
Antineutrophil cytoplasmic antibodies (ANCA) are autoantibodies directed against antigens found in the cytoplasmic granules of neutrophils and monocytes. ANCA testing is usually performed to help diagnose or exclude Wegener's granulomatosis and microscopic polyangiitis. The three most commonly used assays are indirect immunofluorescence (IIF) and the direct and 'capture' enzyme-linked immunosorbent assays (ELISAs) for ANCA directed against proteinase 3 (PR3) and myeloperoxidase (MPO). Although the International Consensus Statement for Testing and Reporting ANCA recommends that all sera are screened for ANCA by IIF and that IIF-positivity is confirmed by direct ELISAs, some laboratories test by direct ELISA alone, others screen with direct ELISA and confirm positive sera by IIF, and a few use capture ELISAs. This chapter discusses the various forms of vasculitis associated with ANCA, the usefulness of each of the ANCA assays and how ANCA testing can be used in the management of patients with small-vessel vasculitis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Best Practice & Research Clinical Rheumatology - Volume 19, Issue 2, April 2005, Pages 263-276
Journal: Best Practice & Research Clinical Rheumatology - Volume 19, Issue 2, April 2005, Pages 263-276
نویسندگان
Judy (Professor of Medicine), Wendy (Laboratory Scientist), Michelle (Laboratory Scientist),