Detection and quantification of proviral HIV-1 184M/V in circulating CD4+ T cells of patients on HAART with a viremia less than 1000 copies/ml

The frequency of the 184V mutation was significantly lower, in the CD4+ T cellular compartment of patients with a viral load of less than 20 copies/ml as compared to patients with a viremia of 20-1000 copies/ml. Viremia, sustained below 20 copies/ml may prevent the appearance of 184V mutation in this reservoir and therefore should be the objective of treatment.