کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9268559 | 1219125 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The natural history and laboratory diagnosis of human herpesviruses-6 and -7 infections in the immunocompetent
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کلمات کلیدی
HHV-6ART-PCRHHV-6BHHV-7HHV-6EBV - اپشتین بار ویروسenzyme immunoassay - ایمونواسی آنزیم EIA - اینreverse transcription PCR - رونویسی معکوس PCRCMV - سیتومگالوویروسcytomegalovirus - سیتومگالوویروسCongenital infection - عفونت مادرزادیCSF - مایع مغزی نخاعیCerebrospinal fluid - مایع مغزی نخاعیEpstein barr virus - ویروس Epstein BarrAntibody avidity - ویروس آنتی بادیHuman herpesvirus-7 - ویروس انسانی انسانی -7human herpesvirus-6 - ویروس هروئین انسان 6
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The natural history and laboratory diagnosis of human herpesviruses-6 and -7 infections in the immunocompetent The natural history and laboratory diagnosis of human herpesviruses-6 and -7 infections in the immunocompetent](/preview/png/9268559.png)
چکیده انگلیسی
Background:Human herpesviruses-6 and -7 (HHV-6/7) are widespread in all populations. In some individuals HHV-6 is found integrated into human chromosomes, which results in a high viral load in blood. HHV-6 variant B (HHV-6B) and HHV-7 primary infections, although usually silent, not infrequently cause the childhood exanthem roseola infantum and are sometimes accompanied by neurological illness. HHV-6 variant A (HHV-6A) is not associated with any disease.Objectives:The present review focuses on the immunocompetent individual and considers the epidemiology of the two viruses and their role as human pathogens. It discusses the importance of satisfactory diagnostic tests to distinguish them, compares those currently available, and recommends how best to differentiate primary from persistent infection in each case.Results:It is explained that at the present time antibody avidity immunofluorescence tests are the most reliable discriminators of the two types of infection. In primary infection these tests can be supplemented by PCR for viral DNA in blood but careful interpretation is required for HHV-6 in view of the high persistent viral DNA load seen with chromosomal integration.Since the contribution of primary HHV-6 and -7 infections to the burden of severe neurological illness in young children is only now emerging as significant, the need to test for these viruses in such cases is stressed.Conclusions:1.Primary HHV-6/7 infections must be distinguished from persistent infections.2.Chromosomal integration of HHV-6 requires urgent study.3.HHV-6A/B must be distinguished in clinical situations.4.Where serious neurological disease/encephalitis is temporally related to immunisation it is particularly important to test for HHV-6/7 primary infection since otherwise the condition might wrongly be diagnosed as a vaccine reaction.5.Because less is currently known about HHV-7 and HHV-6A than HHV-6B, future studies should concentrate on the former two.6.Improvements in diagnostic tests are required for each virus.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Virology - Volume 32, Issue 3, March 2005, Pages 183-193
Journal: Journal of Clinical Virology - Volume 32, Issue 3, March 2005, Pages 183-193
نویسندگان
K.N. Ward,