کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9271432 | 1220026 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A murine model of pulmonary basidiomycosis by Schizophyllum commune
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
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![عکس صفحه اول مقاله: A murine model of pulmonary basidiomycosis by Schizophyllum commune A murine model of pulmonary basidiomycosis by Schizophyllum commune](/preview/png/9271432.png)
چکیده انگلیسی
Schizophyllum commune has recently emerged as a causative agent of human mycosis, but the details of its virulence are not yet known. To elucidate the pathogenicity of S. commune, a murine model of invasive pulmonary infection was established. ICR mice, not immunosuppressed or immunosuppressed by cortisone acetate, were infected with S. commune by intratracheal inoculation with agar beads containing the basidiospores. All immunosuppressed mice died within 2 weeks. Pathology examination revealed massive mycelial invasion into the lungs, penetration into adjacent vessels, and systemic dissemination, suggesting much higher virulence of this fungus than was previously estimated. This is the first murine model of pulmonary infection by S. commune, which we believe can be of assistance during subsequent investigations of this infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Infection and Chemotherapy - Volume 11, Issue 3, 2005, Pages 136-140
Journal: Journal of Infection and Chemotherapy - Volume 11, Issue 3, 2005, Pages 136-140
نویسندگان
Hiromichi Unno, Akira Honda, Takayuki Kuriyama, Katsuhiko Kamei, Kazuko Nishimura,