Effect of hyaluronic acid (MW 500-730Â kDa) on proteoglycan and nitric oxide production in human osteoarthritic chondrocyte cultures exposed to hydrostatic pressure

These in vitro studies confirm both the protective role of HA (MW 500-730 kDa), which counteracts the IL-1β-induced effects, and the importance of pressure on chondrocyte metabolism and morphology.