Variation of serum hyaluronan with activity in individuals with knee osteoarthritis

Although a rise in serum HA with activity and eating has been demonstrated previously in individuals with rheumatoid arthritis, this is the first study to demonstrate a similar rise in individuals with OA. These results suggest that serum sampling for HA in OA clinical trials should be performed more than 1 h after arising in the morning and at least 1 h after breaking an overnight fast.